The Binding of Isaac
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The Binding of Isaac is a video game created by Edmund McMillen and Florian Himsl and released on Steam. It also has a remake titled The Binding of Isaac: Rebirth. Inspired by the Biblical story, the game follows a boy named Isaac. His mother starts hearing a voice she believes is God, causing her to lock him in his room naked. When she thinks she is told to kill her son as an act of devotion, Isaac escapes though a trap door into the basement. Armed with his tears, he struggles to survive the incoming horrors.
An item called the Bucket of Lard makes Isaac fatter, decreasing his speed but giving him a little health.