The Boondocks

WARNING! This media contains realistic depictions of weight gain, which may be unpleasant to certain readers.

The Boondocks is a series created by Aaron McGruder based on the comic of the same name, the series has 4 seasons aired in Adult Swim from November 6, 2005 to June 23, 2014, having a total of 55 episodes.

The Itis (S01E10)

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Janet O'Siren, a woman who used to frequently visit The Itis restaurant gains a lot of weight because she has becomed an adicted to soul food (specifically, the Luther Burger), later after harassing Robert, she ran to the Meadowlark Park to cry about her situation.

At the end of the episode she loses all the weight she has gained.